林伯樵副教授

◆研究室：理4023

◆實驗室：理4023

◆電話：（07）5252000 轉 3913

◆e-mail：pclin@mail.nsysu.edu.tw

◆e-mail：pochaou@yahoo.com.tw

◆實驗室網頁

學經歷

◇中央研究院 國際研究生學程 (化學生物與生物物理學程)
◇暨國立清華大學 化學研究所 博士 (2005-2008)
◇國立台灣師範大學 化學系 碩士 (2001-2003)
◇國立台灣師範大學 化學系 學士 (1997-2001)
◇國立中山大學 化學系 副教授 (2014)
◇國立中山大學 化學系 助理教授 (2010-2014)
◇德國 馬克斯普郎克研究所 分子生理學研究所 博士後研究(Max-Planck Institute for Molecular Physiology, 2009-2010)
◇國立清華大學 化學研究所 博士後研究 (2008)
◇中央研究院 化學研究所 研究助理 (2003-2008)

獎勵與榮譽

◇Asian Core Program Lectureship award (Korea), 2014
◇Asian Core Program Lectureship award (Singapore), 2014
◇國立中山大學年輕學者獎 2014
◇國立中山大學特聘年輕學者 2014
◇Max-Planck research fellowship, Max-Planck Institute, Germany, 2009-2010
◇The Outstanding PhD Thesis Award of Chinese Chemistry Society, 2008 中國化學學會論文傑出獎 (生物化學組)
◇Taiwan International Graduate Program (TIGP) conference grant, 2008
◇Selected as a participant in 1st HOPE meeting, Tsukuba, Japan. Awarded the medal from Dr. Leo Esaki (The Nobel Prize in Physics (1973), March, 2008.
◇The thesis award of Chinese Chemistry Society, 2003 中國化學學會論文優等獎 (有機化學組)
◇The Best Poster Award in the 2nd International OLED and PLED Workshop held by Taiwan Organic and Polymer LEDs Association (TOPLEDA), Taipei, 2003

研究興趣

我們實驗室的研究內容，大致分為四項主題：

1. 有機探針分子的設計及合成，有機合成方法之開發。

2. 開發 發展新穎水相化學鍵結方法並應用於生物分子之共價修飾。進而延伸到固態材料的表面修飾，如奈米粒子或生物晶片。

3. 功能化奈米材料設計 設計及合成功能化奈米材料，結合質譜檢測或光譜分析進而應用在特異性分子的檢測。

3. 化學生物學: 專一位向性蛋白質修飾 將化學的觀念及策略運用在設計功能化的分子，進而研究重要的生物問題上並討論生物大分子的後轉譯修飾及功能。

參與國際會議

  1. XVIIIth International Symposium on Glycoconjugates, 2005, Florence, Italy (title: Effective protein and solid surface modification via 1, 3-dipolar cycloaddition)

  2. Ist International Symposium of Nanomedicine, 2007, Okazaki, Japan (title: Nanoprobe-Based Affinity Mass Spectrometry In Target Detection: From Plasma Proteins to Small Molecules)

  3. XIXth International Symposium on Glycoconjugates, 2007, Cairns, Australia (title: Carbohydrate Encapsulated Magnetic Nanoparticles In Protein Separation And Bacterial Recognition)

  4. Ist HOPE meeting as an invited participant for nanotechnology field, 2008 Feb 24-29, Tsukuba, Japan

  5. LVIth Conference of American Society for Mass Spectrometry (ASMS), 2008, Denver, USA(title: Site-directed Nanoprobe-Basecd Affinity Mass Spectrometry for Multiple Biomarkers Identification and Quantitation)

  6. 2011 亞洲醣科學研討會 中國、上海

  7. 2013 International Symposium of Organic Reactions (ISOR meeting) 台灣、台北

  8. 2014 International Kyoto Symposium of Organic Nanostructures 日本，京都

  9. 2014 Asian Chemical Biology Conference 新加坡

受邀演講

  1. Title: Glyco-Nanomaterials in Biomedical Applications Department of Medical Laboratory Science and Biotechnology, National Cheng-Kung University, 08/2008

  2. Title: Nanoprobe-Based Affinity Mass Spectrometry in Immunoassay 2008 Taipei International Invention Show and Technomart, 09/2008

  3. 奈米生醫材料之開發及應用，奈米醫學研討會，國立中興大學，04/2011

  4. 專一性蛋白質修飾及其在生醫材料之應用，工業研究院 生醫所，06/2011

  5. 中國化學會 專題演講 2013，暨南大學

代表著作

  1. P.-H. Chou, S.-H. Chen, H.-K. Liao, P.-C. Lin, G.-R. Her, Alan C.-Y. Lai, J.-H. Chen, C.-C. Lin,*, Y.-J. Chen,* “Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma” Anal. Chem. 2005, 77, 5990-5997. (SCI, IF:5.712)

  2. P.-C. Lin, P.-H. Chou, S.-H. Chen, H.-K. Liao, K.-Y. Wang, Y.-J. Chen, C.-C. Lin,* “Ethylene Glycol-Protected Magnetic Nanoparticles for a Multiplexed Immunoassay in Human Plasma” Small, 2006, 2, 485-489. (SCI, IF: 6.525)

  3. P.-C. Lin, S.-H. Ueng, M.-C. Tseng, J.-L. Ko, K.-T. Huang, S.-C. Yu, A. K. Adak, Y.-J. Chen, C.-C. Lin,* “Site-Specific Protein Modification through Cui-Catalyzed 1,2,3-Triazole Formation and Its Implementation in Protein Microarray Fabrication“ Angew. Chem. Int. Ed. 2006, 45, 4286-4290. (SCI, IF: 10.879)

  4. P.-C. Lin, M.-C. Tseng, A.-K. Su, Y.-J. Chen*, C.-C. Lin,* “Functionalized Magnetic Nanoparticles for Small-Molecule Isolation, Identification, and Quantification“ Anal. Chem. 2007, 79, 3401-3408. (SCI, IF: 5.712)

  5. P.-C. Lin, S.-H. Ueng, S.-C. Yu, M.-D. Jan, A. K. Adak, C.-C. Yu, C.-C. Lin,* “Surface Modification of Magnetic Nanoparticle via Cu(I)-Catalyzed Alkyne-azide [2 + 3] Cycloaddition” Org. Lett. 2007, 9, 2131-2134.(SCI, IF:5.128)

  6. T.-C. Chiu, L.-S. Huang, P.-C. Lin, Y.-C. Chen, Y.-J. Chen, C.–C. Lin, H.-T. Chang, “Nanomaterial Based Affinity Matrix-assisted Laser Desorption/Ionization Mass Spectrometry for Biomolecules and Pathogenic Bacteria.” Recent patents on Nanotechnology, 2007, 1, 99- 111.

  7. P.-C. Lin, C.-C. Yu, C.-C. Lin* “Site-specific CMP-sialic acid synthetase Immobilized Magnetic Nanoparticle in the synthesis of CMP-sialic acid” Chem. Commun. 2008, 1308-1310. (Co-first authors) (SCI, IF: 5.34)

  8. P.-H. Shih, J.-Y. Shiu, P.-C. Lin, C.-C. Lin, T. Veres, P. Chen, “On chip sorting of bacterial cells using sugar-encapsulated magnetic nanoparticles” J. Appl. Phys. 2008, 103, 07A316.(SCI, IF: 2.171)

  9. K.-Y. Wang, S.-A. Chuang, P.-C. Lin, S.-H. Chen, L.-S. Huang, C.-C. Lin, and Y.-J. Chen* “Multiplexed Immunoassay: Quantitation and Profiling of Serum Biomarkers Using Magnetic Nanoprobes and MALDI-TOF MS“ Anal. Chem., 2008, 80, 6159-6167. (SCI, IF: 5.712)

  10. P.-C. Lin, H.-T. Wu, K.-Y. Wang, Y.-J. Chen, C.-C. Lin, “Development and Application of Functionalized Nanoparticles on Mass Spectrometry for the Analysis of Target Biomolecules” Instruments Today, 2008, 29, 68. (in Taiwan)

  11. P.-C. Lin, S.-H. Chen, M.-L. Chen, A. Kumar Adak, Y.-J. Chen* and C.-C. Lin*, “Site-specific Immobilization of Antibody on the Magnetic Nanoparticle via Boronate Formation” Anal. Chem. 2009, 81, 8774. (SCI, IF: 5.712)

  12. P.-C. Lin, A. K. Adak, S.-H. Ueng, L.-D. Huang, K.-T.Huang, C.-C. Lin, “DAST-Mediated Regioselective Anomeric Group Migration in Saccharides”, J. Org. Chem. 2009, 74, 4041-4048. (SCI, IF:3.952)

  13. H.-T. Wu, C.-C. Hsu, C.-F. Tsai, P.-C. Lin, C.-C. Lin* and Y.-J. Chen,” Nanoprobe-based Immobilized Metal Affinity Chromatography for Enhanced Enrichment of Multiply Phosphorylated Peptides” J. Proteome Res. 2009, in revised.(SCI, IF: 5.15)

  14. P.-C. Lin, D. Weinrich, H. Waldmann, ?Protein Biochips: Oriented Surface Immobilization of Proteins“Marcromol. Chem. Phys. 2010, 211, 136-144.

  15. D. Weinrich, P.-C. Lin, P. Jonkheijm, H. Schroder, C. M. Niemeyer, K. Alexandrov, H. Waldmann. ?Oriented Immobilization of Farnesylated Proteins by Thiol-Ene Reaction “Angew. Chem. Int. Ed. 2010, 49,1252-1257. (SCI, IF: 10.879)

  16. A. K. Adak, M.-L. Chen, C.-H. Lai, P.-C. Lin, C.-C. Lin, “Rapid and Ultrasensitive Glyconanoparticles/Microarray-Based Label-Free Detection of Toxin by Naked eye”, ChemBioChem 2010, in submitted.

  17. M.-C. Tseng, R. Obena, Y.-W. Lu, P.-C. Lin, P.-Y. Lin, Y.-S. Yen, J.-T. Lin, L.-D. Huang, K.-L. Lu, L.-L. Lai, C.-C. Lin, Y.-J. Chen “Dihydrobenzoic Acid Modified Nanoparticle as a MALDI-TOF MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures”J. Am. Soc. Mass Spectrom. 2010, 11, 1930.

  18. W.-C. Chen, P.-C. Lin, C.-H. Chen, C.-T. Chen, Chem. Euro. J. 2010, 43, 12822.

  19. H.-T. Wu, C.-C. Hsu, C.-F. Tsai, P.-C. Lin, C.-C. Lin* and Y.-J. Chen,” Nanoprobe-based Immobilized Metal Affinity Chromatography for Enhanced Enrichment of Multiply Phosphorylated Peptides” Proteomics 2011, 11, 2639.

  20. R. P. Obena, P.-C. Lin, Y.-W. Lu, I.-C. Li, F. Del Mundo, S. D. Arco, G.M. Nuesca, C.-C. Lin, Y.-J. Chen, “Iron oxide nanomatrix facilitating metal ionization in matrix-assisted laser desorption/ionization mass spectrometry.”Anal. Chem. 2011, 83, 9337.

  21. Yi L, Chen YX, Lin PC, Schröder H, Niemeyer CM, Wu YW, Goody RS, Triola G, Waldmann H., “Direct immobilization of oxyamine-modified proteins from cell lysates” Chem. Commun. 2012, 48, 10829-10831.

  22. Po-Chiao Lin,* Ching-Ching Yu, Huan-Ting Wu, Ying-Wei Lu, Chia-Li Han, An-Kai Su, Yu-Ju Chen,* Chun-Cheng Lin,* “A Chemically Functionalized Magnetic Nanoplatform for Rapid and Specific Biomolecular Recognition and Separation” Biomacromolecule 2013, 14, 160-168. (*corresponding author; ) (SCI impact factor:5.788, ranking: 4/82 in polymer science; 4.87%)

  23. Yung-Lin Yang, Basker Rajagopal, Chien-Fu Liang, Chun-Chi Chen, Hsiu-Ping Lai, Chih-Hung Chou, Yen-Pin Lee, Yen-Ling Yang, Jing-Wen Zeng, Chun-Lin Ou, Po-Chiao Lin,* “Chemoselective Synthesis of Aryl Carboxamido Sulfonic Acid Derivatives” Tetrahedron 2013, 69, 2640-2646. (*corresponding author; DOI: 10.1016/j.tet.2013.01.028) (SCI impact factor: 2.817, ranking: 17/58 in organic chem)

  24. Chun-Chi Chen, Yung-Lin Yang, Chun-Lin Ou, Chih-Hung Chou, Chih-Chuang Liaw, and Po-Chiao Lin,* “Direct Monitoring of Chemical Transformations by Combining Thin Layer Chromatography with Nanoparticle-assisted Laser Desorption/Ionization Mass Spectrometry” Analyst 2013,138, 1379-1385. (*corresponding author, selected as the HOT article) (SCI impact factor:3.906, ranking: 7/76 in Analytical Chem)

  25. Lu YW, Chien CW, Lin PC, Huang LD, Chen CY, Wu SW, Han CL, Khoo KH, Lin CC, Chen YJ.” BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for the Selective Enrichment of Glycoproteins.”Anal. Chem. 2013, 85, 8268-76. (SCI impact factor:5.825, ranking: 4/76 in Analytical Chem)

  26. Hsieh S, Hsieh SL, Hsieh CW, Lin PC, Wu CH “Label-free glucose detection using cantilever sensor technology based on gravimetric detection principles“ J. Anal. Methods. Chem. 2013 (doi: 10.1155/2013/687265.) 25. Yang MH, Wang HY, Lu CY, Tsai WC, Lin PC, Su SB, Tyan YC. “Proteomic profiling for peritoneal dialysate: differential protein expression in diabetes mellitus” Biomed. Res. Int. 2013 (doi: 10.1155/2013/642964.)

  27. Yung-Lin Yang, Yen-Pin Lee, Yen-Ling Yang, Po-Chiao Lin* “Traceless Labeling of Glycoproteins and Its Application to the Study of Glycoprotein-protein Interact” ACS Chem. Biol. 2014, 9, 390-397. (*corresponding author) （SCI impact factor:5.356, ranking: 51/291 in Biochemistry & Molecular Biology)

  28. Chun-Chi Chen, Basker Rajagopal, Xuan Yu Liu, Kuan Lin Chen, Yu-Chang Tyan, FuI Lin, and Po-Chiao Lin* “A Mild Removal of Fmoc Groups by Sodium Azide” Amino Acids 2014, 46, 367-374. (*corresponding author) (SCI impact factor:3.653, ranking: 97/291 in Biochemistry & Molecular Biology)

  29. B. Rajagopal, Y.g-Y. Chen, C.-C. Chen, X.-Y. Liu, H.-R. Wang, P.-C. Lin* “Cu(I)-Catalyzed Synthesis of Dihydropyrimidin-4-ones toward the Preparation of β- and β3- Amino Acid Analogues”J. Org. Chem. 2014, 79, 1254-1264. (SCI impact factor:4.638, ranking: 8/58 in Chemistry Organic)

  30. B. Rajagopal, C.-H. Chou, C.-C. Chung, P.-C. Lin, “Synthesis of Substituted 3-Indolylimines and Indole-3-carboxaldehydes by Rhodium(II)-Catalyzed Annulation. Org. Lett. 2014, 16, 3752. (SCI impact factor:6.324, ranking: 3/58 in Chemistry Organic)

  31. Yang, Ming-Hui; Yuan, Shyng-Shiou; Chung, Tze-Wen; Jong, Shiang-Bin; Lu, Chi-Yu; Tsai, Wan-Chi; Chen, Wen-Cheng; Lin, Po-Chiao; Chiang, Pei-Wen; Tyan, Yu-ChangCharacterization of silk fibroin modified surface: a proteomic view of cellular response proteins induced by biomaterials BioMed Research International (2014), 209469/1-209469/12

  32. Yang, Ming-Hui; Yuan, Shyng-Shiou; Chen, Yi-Ling; Chu, Pei-Yu; Jong, Shiang-Bin; Huang, Ying-Fong; Lu, Chi-Yu; Lu, Yi-Shan; Lin, Po-Chiao; Tyan, Yu-Chang Mass spectrometry in clinical diagnosis: a preliminary application in tumor cellular proteomics for biomarker discovery Journal of Analytical & Bioanalytical Techniques (2014), (Spec.Issue12), 009/1-009/13, 13 pp

  33. Yang, Ming-Hui; Yuan, Shyng-Shiou; Huang, Ying-Fong; Lin, Po-Chiao; Lu, Chi-Yu; Chung, Tze-Wen; Tyan, Yu-ChangA proteomic view to characterize the effect of chitosan nanoparticle to hepatic cells: is chitosan nanoparticle an enhancer of PI3K/AKT1/mTOR pathway? BioMed Research International (2014), 789591/1-789591/10.

  34. Yang, Ming-Hui; Chung, Tze-Wen; Lu, Yi-Shan; Chen, Yi-Ling; Tsai, Wan-Chi; Jong, Shiang-Bin; Yuan, Shyng-Shiou; Liao, Pao-Chi; Lin, Po-Chiao; Tyan, Yu-Chang Activation of the ubiquitin proteasome pathway by silk fibroin modified chitosan nanoparticles in hepatic cancer cells International Journal of Molecular Sciences (2015), 16(1), 1657-1676

  35. Chou, Chih-Hung; Chen, Ying-Yu; Rajagopal, Basker; Tu, Hsiu-Chung; Chen, Kuan-Lin; Wang, Shen-Fu; Liang, Chien-Fu; Tyan, Yu-Chang; Lin, Po-Chiao “Thermally Induced Denitrogenative Annulation for the Synthesis of Dihydroquinolinimines and Chroman-4-imines” Chem. Asian J. 2016, 11, 757–765

專利
  1. Y.-J. Chen, P.-C. Lin, C.-C. Lin, S.-H. Chen, P.-H. Chou, H.-K. Liao (2007): Mass spectrometric analysis of ligand conjugated magnetic nanoparticles, U. S. Appl. Publ. US20070054407
  2. Po-Chiao Lin, Chun-Chi Chen (2013): 利用薄層層析質譜分析化合物的方法 （中華民國專利申請中）

書籍文章
  1. L.-S. Huang, Y.-Y. Chien, S.-H. Chen, P.-C. Lin, K.-Y. Wang, P.-H. Chou, C.-C. Lin, and Y.-J. Chen,“Nanoprobe-based Affinity Mass Spectrometry for Cancer Marker Protein Profiling”in Nanomaterials for Cancer Diagnosis; Eds: Challa S. S. R. Wiley-VCH, 2007
  2. P.-C. Lin, A. Kumar Adak, and C.-C. Lin*,“Application of glycol-nanomaterial in the biological system” in The Molecular Immunology of Complex Carbohydrates-3; Eds: Albert M. Wu, Kluwer Academia/Plenum Publishers, 2011
  3. Wei-Ting Chien, Ching-Ching Yu, Chien-Fu Liang, Chien-Hui Lai, Po-Chiao Lin,* Chun-Cheng Lin,* Functionalized glyconanoparticles for the study of glycobiology” in Glyco-nanotechnology as a bridge to new medicines, ACS Symposium Series 10