Dr Ong, Chi-wi

Office:C3019     Lab:C6014

Tel:(07)5252000 ext 3923

e-mail:cong@mail.nsysu.edu.tw

cw_ong.jpg (87259 bytes)

Visiting Professor, University Sains, Malaysia(1995)
Professor(1987)
Associate Professor(1983)
Postdoctoral Research Associate,

University of Alberta, Canada(1982)
Ph.D., Cambridge, UK(1982)
B.S.(Hon) Liverpool University, UK(1979)

Awards and Honors

Pfiffer Scholar, Girton College, Cambridge.

 

Research Interest

1.Organometallic- Development of new applications of organoiron complexes in organic
   synthesis.

2.Development of new synthetic methodology.

3.Development of new antitumor agents based on mechanism of action.

 

Selected Publications

1.          L. L. Wei, M. C. Lai, C. W. Ong, Radical Addition to Tricarbonyl[(1-4-��)-2-methoxy-5-methylene-cyclohexa-1,3-diene]iron , Tetrahedron Letts., 2000, 41, 3407.

2.          S. Y. Lee, M. D. Wu, C. W. Wang(Ong), Y. H. Kuo, R. L. Huang, K. H. Lee, A Novel Anti-HbeAg Homolignan, Taiwanschirin D from Kadsura matsudai, Chem. Pharm. Bull. 2000, 48, 1992.

3.           P. C. Shieh; C. W. Ong; Metal carbenoid mediated ring opening of furan-2-yloxy derivatives. Stereoselective synthesis of 2,4-hexadienedioic acid and 6-aryl-1-oxo-2,4-hexadienoic acid derivatives, Tetrahedron, 2001, 57, 7303.

4.          C. W. Ong; M. C Lai. Y. A Chang. Pyrrolizine and Indolizine Derivatives from 1,6-Dioxo-2,4-diene by Inter- and Intramolecular Ring Closure, Heterocycles, 2002, 57, 1303.

5.          C. W. Ong; M.. C Lai. Triene-Tricarbonyl Complexes in Organic Synthesis Trends in Organometallics Chemistry, 2002, vol. 4, 47-58.

6.          A. P. Deng, H. T. Liu, S. J. Jiang, H. J. Huang, C. W. Ong. Reaction Cell Inductively Coupled Plasma Mass Spectrometry-based Immunoassay Using Ferrocene Tethered Hydroxysuccimide Ester as Label for the Determination of 2,4-Dichlorophenoxyacetic Acid, Anal. Chim. Acta, 2002, 472, 55-61.

7.          C. W. Ong, J-L. Han, Some Aspects of Anticancer Drug Activation, Chin. Pharm. J. (review) 2002, 54, 313-329.

8.          C. W. Ong, S-C. Liao, T-H. Chang, H-F. Hsu. Rapid synthesis of new discotic liquid crystals based on diquinoxalino[2,3-a:2’3’-c]phenazine containing hexakis(alkoxy) side arms. Tetrahedron Letts, 2003, 44, 1477-1480.

9.          Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea Y-H. Kuo, A-S. Yu, M-D. Wu, C. W Ong, L-M. Y. Kuo, J-T. Huang, C-F. Chen, S-Y. Li Chem. Pharm. Bull. 2003, 51, 425-426.

10.      C. W. Ong, Y-A Chang. Novel Design of Pentacyclic Scaffold that simulate Saframycin Binding Domains. Tetrahedron, 2003, 59, 8245-8252.

11.      C. W. Ong; C. Y. Yu; Electronic Control of Product Formation: Rearrangement of 1,3-Dithian-2-yl-arylmethanols. Tetrahedron, 2003, 59, 9677-9682.

12.      M. D. Wu, R-L Huang, L-M Yang Kuo, C-C. Hung, C. W. Ong, Y-H. Kuo. The Anti-HbsAg (Human Type B Hepatitis, Surface Antigen) and Anti HbeAg (Human B Hepatitis, e Antigen) C18 Dibenzocyclooctadiene Lignans from Kadsura matsudai and Schizandra arisanensis. Chem. Pharm. Bull. 2003, 51, 1233-1236.

13.      C. W. Ong, S-C. Liao, T-H Chang, H-F. Hsu,       In Situ Synthesis and Mesogenic Properties of the Electron Deficient Discotic Hexakis(alkoxy)hexaazatrinaphthylene Compounds, J. Org. Chem. 2004, 69, 3181-3186.

14.      J. L. Han, C. W. Ong, Reaction of Tricarbonyl[(1-4-h)-2-methoxy-5-vinylidene- cyclohexa-1,3-diene]iron Derivatives with Carbene: (2 + 1) Cycloaddition for the Rapid Synthesis of Spiro[2,5]octane, Tetrahedron. 2005, 61, 1501-1507.

15.      Y-H. Kuo, M. D. Wu, C-C. Hung, R-L Huang, L-M Yang Kuo, Y. C. Shen, C. W. Ong, Synthesis pf C18 Dibenzocyclooctadiene Ligand Derivatives as Anti-HBsAg and Anti HBeAg Agents, Bioorg. Med. Chem. 2005, 13, 1555-1561.

16.      S-S. Juang, Michael Chang, L.  F. Wang, M. C. Lai, C. W. Ong, One Pot Synthesis of Fused [1, 2-a]Pyrrole from 1,6-Dioxo-2,4-diene and Haloalkyl Primary Amine, Tetrahedron. 2005, 61, 1693-1697.  

17.      Hsu, H.-F.; Chien, S.-J.; Chen, S.-H.; Chen, C.-H.; Huang, L.-Y.; Kou, C.-H.; Chen, K.-J.; Ong, C. W.; Wong, K.-T., “Mesogenic and optical properties of a,a'-bis(4-alkoxy-phenylethynyl) oligothiophenes,” Liq. Cryst., 2005, (accepted for publication, Dec, 2004).