王志偉教授

研究室:C3019
實驗室:C6014

電話:(07)5252000 ext 3923

學經歷:

馬來西亞科技大學訪問教授(1995)
教授(1987)
副教授(1983)
加拿大亞伯達大學抗癌中心博士後研究(1982)

英國劍橋大學化學博士(1982)

英國利物浦大學學士(1979)

獎勵與榮譽：

研究興趣:

本實驗室主要研究著重在有機金屬在有機合成上的運用，及反應機構的探討，特別是1.3環乙烯三羰基鐵錯合物。在基本研究上，我們希望瞭解取代基在三羰基鐵錯合物所扮演的角色，對反應性、特位選擇性和立體化學的影響。我們也希望建立新的合成方法，得具有高純度的光化學活性三羰基鐵錯合物及開發新的合成應用。

另一個主要研究方向是在生物有機，特別對藥物的合成設計和機構，如saframycin和bleomycin。天然界的抗癌藥物都有很嚴重的負作用，對於已瞭解的抗癌藥物之反應機構，我們希望設計出具有高抗癌藥效及低負作用的新一代藥物。

在材料方面上，盤狀液晶（discotic liquid crystals）是一種具有剛硬的芳香環核心，以及具有分支的側鏈，能夠自動排列成管柱狀，此特殊性質應有很多的用途，因此，本實驗室的研究方向則是著重於以HAT為主體來快速有效的合成新的盤狀液晶及盤狀液晶的應用。

Fig. 1 小分子與DNA鍵結模型

Fig. 2 材料的研究方向

1.  L. L. Wei, M. C. Lai, C. W. Ong, Radical Addition to Tricarbonyl[(1-4-h)-2-methoxy-5-methylene-cyclohexa-1,3-diene]iron , Tetrahedron Letts., 2000, 41, 3407.

2.  S. Y. Lee, M. D. Wu, C. W. Wang(Ong), Y. H. Kuo, R. L. Huang, K. H. Lee, A Novel Anti-HbeAg Homolignan, Taiwanschirin D from Kadsura matsudai, Chem. Pharm. Bull. 2000, 48, 1992.

3.   P. C. Shieh; C. W. Ong; Metal carbenoid mediated ring opening of furan-2-yloxy derivatives. Stereoselective synthesis of 2,4-hexadienedioic acid and 6-aryl-1-oxo-2,4-hexadienoic acid derivatives, Tetrahedron, 2001, 57, 7303.

4.  C. W. Ong; M. C Lai. Y. A Chang. Pyrrolizine and Indolizine Derivatives from 1,6-Dioxo-2,4-diene by Inter- and Intramolecular Ring Closure, Heterocycles, 2002, 57, 1303.

5.  C. W. Ong; M.. C Lai. Triene-Tricarbonyl Complexes in Organic Synthesis Trends in Organometallics Chemistry, 2002, vol. 4, 47-58.

6.  A. P. Deng, H. T. Liu, S. J. Jiang, H. J. Huang, C. W. Ong. Reaction Cell Inductively Coupled Plasma Mass Spectrometry-based Immunoassay Using Ferrocene Tethered Hydroxysuccimide Ester as Label for the Determination of 2,4-Dichlorophenoxyacetic Acid, Anal. Chim. Acta, 2002, 472, 55-61.

7.  C. W. Ong, J-L. Han, Some Aspects of Anticancer Drug Activation, Chin. Pharm. J. (review) 2002, 54, 313-329.

8.  C. W. Ong, S-C. Liao, T-H. Chang, H-F. Hsu^. Rapid synthesis of new discotic liquid crystals based on diquinoxalino[2,3-a:2’3’-c]phenazine containing hexakis(alkoxy) side arms. Tetrahedron Letts, 2003, 44, 1477-1480.

9.  Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea Y-H. Kuo, A-S. Yu, M-D. Wu, C. W Ong, L-M. Y. Kuo, J-T. Huang, C-F. Chen, S-Y. Li Chem. Pharm. Bull. 2003, 51, 425-426.

10.  C. W. Ong, Y-A Chang. Novel Design of Pentacyclic Scaffold that simulate Saframycin Binding Domains. Tetrahedron, 2003, 59, 8245-8252.

11.  C. W. Ong; C. Y. Yu; Electronic Control of Product Formation: Rearrangement of 1,3-Dithian-2-yl-arylmethanols. Tetrahedron, 2003, 59, 9677-9682.

12.  M. D. Wu, R-L Huang, L-M Yang Kuo, C-C. Hung, C. W. Ong, Y-H. Kuo. The Anti-HbsAg (Human Type B Hepatitis, Surface Antigen) and Anti HbeAg (Human B Hepatitis, e Antigen) C₁₈ Dibenzocyclooctadiene Lignans from Kadsura matsudai and Schizandra arisanensis. Chem. Pharm. Bull. 2003, 51, 1233-1236.

13.  C. W. Ong, S-C. Liao, T-H Chang, H-F. Hsu,     In Situ Synthesis and Mesogenic Properties of the Electron Deficient Discotic Hexakis(alkoxy)hexaazatrinaphthylene Compounds, J. Org. Chem. 2004, 69, 3181-3186.

14. L. Han, C. W. Ong, Reaction of Tricarbonyl[(1-4-h)-2-methoxy-5-vinylidene-cyclohexa- 1,3-diene]iron Derivatives with Carbene: (2 + 1) Cycloaddition for the Rapid Synthesis of Spiro[2,5]octane, Tetrahedron , 2005, 61,1501-1507.

15.       Y-H. Kuo, M. D. Wu, C-C. Hung, R-L Huang, L-M Yang Kuo, Y. C. Shen, C. W. Ong, Synthesis pf C₁₈ Dibenzocyclooctadiene Lignan Derivatives as Anti-HBsAg and Anti HBeAg Agents, Bioorg. Med. Chem.. 2005, 13, 1555-1561.

 16.  S-S. Juang, Michael Chang, L.  F. Wang, M. C. Lai, C. W. Ong, One Pot Synthesis of Fused [1,2-a]Pyrrole from 1,6-Dioxo-2,4-diene and Haloalkyl Primary Amine, Tetrahedron, 2005, 61, 1693-1697.

17. H.-F. Hsu, S.-J..Chien, S.-H. Chen, C.-H. Chen, L.-Y. Huang, C.-H. Kou, K.-J. Chen, C. W. Ong, K.-T. Wong “Mesogenic and optical properties of a,a'-bis(4-alkoxy-phenylethynyl) oligothiophenes,” Liq. Cryst., 2005, 32, 683-689.

18. Y-H. Kuo, M. D. Wu , R-L Huang, L-M Yang Kuo, Y-W Hsu, C-C. Liaw, C-C. Hung, Y. C. Shen, C. W. Ong, Antihepatitis Activity (Anti-HBsAg and Anti HBeAg ) of C₁₉ Homolignans and Six Novel C₁₈ Dibenzocyclooctadiene Lignans from Kadsura japonica. Planta Medica, 2005, 71, 646-653. 

19. T-H. Chang, P-J Wu, Michael Y. Chiang, S-C.Liao, C. W. Ong^*, Hsiu-Fu Hsu,‡ and Shu-Yu Lin‡  Synthesis and Mesomorphic Behavior of a Donor-Acceptor-Type Hexaazatriphenylene Organic Letters, 2005, 7, 4075-4078.