王志偉教授

◆研究室:C3019

◆實驗室:C6014

◆電話:(07)5252000 轉 3923

◆e-mail:cong@mail.nsysu.edu.tw


學經歷

◇馬來西亞科技大學訪問教授(1995)
◇教授(1987)
◇副教授(1983)
◇加拿大亞伯達大學抗癌中心博士後研究(1982)
◇英國劍橋大學化學博士(1982)
◇英國利物浦大學學士(1979))


獎勵與榮譽

◇劍橋大學葛敦學院永久費佛學者


研究興趣

   本實驗室主要研究著重在有機金屬在有機合成上的運用,及反應機構的探討,特別是1.3環乙烯三羰基鐵錯合物。 在基本研究上,我們希望瞭解取代基在三羰基鐵錯合物所扮演的角色,對反應性、特位選擇性和立體化學的影響。 我們也希望建立新的合成方法,得具有高純度的光化學活性三羰基鐵錯合物及開發新的合成應用。

   另一個主要研究方向是在生物有機,特別對藥物的合成設計和機構,如saframycin和bleomycin。 天然界的抗癌藥物都有很嚴重的負作用,對於已瞭解的抗癌藥物之反應機構,我們希望設計出具有高抗癌藥效及低負作用的新一代藥物。

   在材料方面上,盤狀液晶(discotic liquid crystals)是一種具有剛硬的芳香環核心, 以及具有分支的側鏈,能夠自動排列成管柱狀,此特殊性質應有很多的用途, 因此,本實驗室的研究方向則是著重於以HAT為主體來快速有效的合成新的盤狀液晶及盤狀液晶的應用。

Fig. 1 小分子與DNA鍵結模型

Fig. 2 材料的研究方向


代表著作

  1. L. L. Wei, M. C. Lai, C. W. Ong, Radical Addition to Tricarbonyl[(1-4-h)-2-methoxy-5-methylene-cyclohexa-1,3-diene]iron , Tetrahedron Letts., 2000, 41, 3407.

  2. S. Y. Lee, M. D. Wu, C. W. Wang(Ong), Y. H. Kuo, R. L. Huang, K. H. Lee, A Novel Anti-HbeAg Homolignan, Taiwanschirin D from Kadsura matsudai, Chem. Pharm. Bull. 2000, 48, 1992.

  3. P. C. Shieh; C. W. Ong; Metal carbenoid mediated ring opening of furan-2-yloxy derivatives. Stereoselective synthesis of 2,4-hexadienedioic acid and 6-aryl-1-oxo-2,4-hexadienoic acid derivatives, Tetrahedron, 2001, 57, 7303.

  4. C. W. Ong; M. C Lai. Y. A Chang. Pyrrolizine and Indolizine Derivatives from 1,6-Dioxo-2,4-diene by Inter- and Intramolecular Ring Closure, Heterocycles, 2002, 57, 1303.

  5. C. W. Ong; M.. C Lai. Triene-Tricarbonyl Complexes in Organic Synthesis Trends in Organometallics Chemistry, 2002, vol. 4, 47-58.

  6. A. P. Deng, H. T. Liu, S. J. Jiang, H. J. Huang, C. W. Ong. Reaction Cell Inductively Coupled Plasma Mass Spectrometry-based Immunoassay Using Ferrocene Tethered Hydroxysuccimide Ester as Label for the Determination of 2,4-Dichlorophenoxyacetic Acid, Anal. Chim. Acta, 2002, 472, 55-61.

  7. C. W. Ong, J-L. Han, Some Aspects of Anticancer Drug Activation, Chin. Pharm. J. (review) 2002, 54, 313-329.

  8. C. W. Ong, S-C. Liao, T-H. Chang, H-F. Hsu. Rapid synthesis of new discotic liquid crystals based on diquinoxalino[2,3-a:2’3’-c]phenazine containing hexakis(alkoxy) side arms. Tetrahedron Letts, 2003, 44, 1477-1480.

  9. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea Y-H. Kuo, A-S. Yu, M-D. Wu, C. W Ong, L-M. Y. Kuo, J-T. Huang, C-F. Chen, S-Y. Li Chem. Pharm. Bull. 2003, 51, 425-426.

  10. C. W. Ong, Y-A Chang. Novel Design of Pentacyclic Scaffold that simulate Saframycin Binding Domains. Tetrahedron, 2003, 59

  11. C. W. Ong; C. Y. Yu; Electronic Control of Product Formation: Rearrangement of 1,3-Dithian-2-yl-arylmethanols. Tetrahedron, 2003, 59, 9677-9682.

  12. M. D. Wu, R-L Huang, L-M Yang Kuo, C-C. Hung, C. W. Ong, Y-H. Kuo. The Anti-HbsAg (Human Type B Hepatitis, Surface Antigen) and Anti HbeAg (Human B Hepatitis, e Antigen) C18 arisanensis. Chem. Pharm. Bull. 2003, 51, 1233-1236.

  13. C. W. Ong, S-C. Liao, T-H Chang, H-F. Hsu, In Situ Synthesis and Mesogenic Properties of the Electron Deficient Discotic Hexakis(alkoxy)hexaazatrinaphthylene Compounds, J. Org. Chem. 2004, 69, 3181-3186.

  14. L. Han, C. W. Ong, Reaction of Tricarbonyl[(1-4-h)-2-methoxy-5-vinylidene-cyclohexa- 1,3-diene]iron Derivatives with Carbene: (2 + 1) Cycloaddition for the Rapid Synthesis of Spiro[2,5]octane, Tetrahedron , 2005, 61,1501-1507.

  15. Y-H. Kuo, M. D. Wu, C-C. Hung, R-L Huang, L-M Yang Kuo, Y. C. Shen, C. W. Ong, Synthesis pf C18 Dibenzocyclooctadiene Lignan Derivatives as Anti-HBsAg and Anti HBeAg Agents, Bioorg. Med. Chem. 2005, 13, 1555-1561.

  16. S-S. Juang, Michael Chang, L. F. Wang, M. C. Lai, C. W. Ong, One Pot Synthesis of Fused [1,2-a]Pyrrole from 1,6-Dioxo-2,4-diene and Haloalkyl Primary Amine, Tetrahedron, 2005, 61, 1693-1697.

  17. H.-F. Hsu, S.-J..Chien, S.-H. Chen, C.-H. Chen, L.-Y. Huang, C.-H. Kou, K.-J. Chen, C. W. Ong, K.-T. Wong “Mesogenic and optical properties of a,a'-bis(4-alkoxy-phenylethynyl) oligothiophenes,” Liq. Cryst., 2005, 32, 683-689.

  18. Y-H. Kuo, M. D. Wu , R-L Huang, L-M Yang Kuo, Y-W Hsu, C-C. Liaw, C-C. Hung, Y. C. Shen, C. W. Ong, Antihepatitis Activity (Anti-HBsAg and Anti HBeAg ) of C19 Homolignans and Six Novel C18 Dibenzocyclooctadiene Lignans from Kadsura japonica. Planta Medica, 2005, 71, 646-653.

  19. T-H. Chang, P-J Wu, Michael Y. Chiang, S-C.Liao, C. W. Ong*, Hsiu-Fu Hsu,‡ and Shu-Yu Lin‡ Synthesis and Mesomorphic Behavior of a Donor-Acceptor-Type Hexaazatriphenylene Organic Letters, 2005, 7, 4075-4078.